5XZR
The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b
Summary for 5XZR
Entry DOI | 10.2210/pdb5xzr/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine (3 entities in total) |
Functional Keywords | phosphatase, sh2 domain, allosteric inhibitor, cancer, signaling protein, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q06124 |
Total number of polymer chains | 1 |
Total formula weight | 64242.55 |
Authors | |
Primary citation | Xie, J.,Si, X.,Gu, S.,Wang, M.,Shen, J.,Li, H.,Shen, J.,Li, D.,Fang, Y.,Liu, C.,Zhu, J. Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment. J. Med. Chem., 60:10205-10219, 2017 Cited by PubMed: 29155585DOI: 10.1021/acs.jmedchem.7b01520 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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