Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5XZR

The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0001784molecular_functionphosphotyrosine residue binding
A0004721molecular_functionphosphoprotein phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0004726molecular_functionnon-membrane spanning protein tyrosine phosphatase activity
A0005158molecular_functioninsulin receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006470biological_processprotein dephosphorylation
A0006629biological_processlipid metabolic process
A0006641biological_processtriglyceride metabolic process
A0007165biological_processsignal transduction
A0007173biological_processepidermal growth factor receptor signaling pathway
A0007229biological_processintegrin-mediated signaling pathway
A0007409biological_processaxonogenesis
A0007420biological_processbrain development
A0007507biological_processheart development
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009755biological_processhormone-mediated signaling pathway
A0009967biological_processpositive regulation of signal transduction
A0016311biological_processdephosphorylation
A0019221biological_processcytokine-mediated signaling pathway
A0019901molecular_functionprotein kinase binding
A0021697biological_processcerebellar cortex formation
A0030159molecular_functionsignaling receptor complex adaptor activity
A0030220biological_processplatelet formation
A0030971molecular_functionreceptor tyrosine kinase binding
A0031295biological_processT cell costimulation
A0032331biological_processnegative regulation of chondrocyte differentiation
A0032480biological_processnegative regulation of type I interferon production
A0032528biological_processmicrovillus organization
A0032728biological_processpositive regulation of interferon-beta production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032991cellular_componentprotein-containing complex
A0033628biological_processregulation of cell adhesion mediated by integrin
A0033629biological_processnegative regulation of cell adhesion mediated by integrin
A0035264biological_processmulticellular organism growth
A0035265biological_processorgan growth
A0035335biological_processpeptidyl-tyrosine dephosphorylation
A0035855biological_processmegakaryocyte development
A0036302biological_processatrioventricular canal development
A0038127biological_processERBB signaling pathway
A0042445biological_processhormone metabolic process
A0042593biological_processglucose homeostasis
A0043254biological_processregulation of protein-containing complex assembly
A0043408biological_processregulation of MAPK cascade
A0045296molecular_functioncadherin binding
A0045778biological_processpositive regulation of ossification
A0045931biological_processpositive regulation of mitotic cell cycle
A0046326biological_processpositive regulation of glucose import
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046676biological_processnegative regulation of insulin secretion
A0046825biological_processregulation of protein export from nucleus
A0046887biological_processpositive regulation of hormone secretion
A0046888biological_processnegative regulation of hormone secretion
A0048008biological_processplatelet-derived growth factor receptor signaling pathway
A0048011biological_processneurotrophin TRK receptor signaling pathway
A0048013biological_processephrin receptor signaling pathway
A0048609biological_processmulticellular organismal reproductive process
A0048806biological_processgenitalia development
A0048839biological_processinner ear development
A0048873biological_processhomeostasis of number of cells within a tissue
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050839molecular_functioncell adhesion molecule binding
A0051428molecular_functionpeptide hormone receptor binding
A0051463biological_processnegative regulation of cortisol secretion
A0060020biological_processBergmann glial cell differentiation
A0060090molecular_functionmolecular adaptor activity
A0060125biological_processnegative regulation of growth hormone secretion
A0060325biological_processface morphogenesis
A0060338biological_processregulation of type I interferon-mediated signaling pathway
A0061582biological_processintestinal epithelial cell migration
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071364biological_processcellular response to epidermal growth factor stimulus
A1990782molecular_functionprotein tyrosine kinase binding
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue 8J6 A 601
ChainResidue
ATHR108
ATHR253
ALEU254
APRO491
ALYS492
AGLU110
AARG111
APHE113
AASN217
ATHR218
ATHR219
AGLU249
AGLU250

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG
ChainResidueDetails
AVAL457-GLY467

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Phosphocysteine intermediate
ChainResidueDetails
ACYS459

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP425
ACYS459
AGLN506

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylthreonine => ECO:0007744|PubMed:19413330
ChainResidueDetails
ATHR2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR62

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P35235
ChainResidueDetails
ATYR66

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon