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4XZ1

ZAP-70-tSH2:Compound-B adduct

Summary for 4XZ1
Entry DOI10.2210/pdb4xz1/pdb
Related4XZ0
DescriptorTyrosine-protein kinase ZAP-70, doubly phosphorylated ITAM peptide, 2-[(7-chloro-4-nitro-2,1,3-benzoxadiazol-5-yl)amino]ethanol (3 entities in total)
Functional Keywordstyrosine kinase, cysteine adduct, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight32450.05
Authors
Barros, T.,Kuriyan, J.,Winger, J.A.,Visperas, P.R. (deposition date: 2015-02-03, release date: 2015-07-29, Last modification date: 2023-11-15)
Primary citationVisperas, P.R.,Winger, J.A.,Horton, T.M.,Shah, N.H.,Aum, D.J.,Tao, A.,Barros, T.,Yan, Q.,Wilson, C.G.,Arkin, M.R.,Weiss, A.,Kuriyan, J.
Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.
Biochem. J., 465:149-161, 2015
Cited by
PubMed: 25287889
DOI: 10.1042/BJ20140793
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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