8DCX

PI 3-kinase alpha with nanobody 3-159

Summary for 8DCX

Entry DOI	10.2210/pdb8dcx/pdb
EMDB information	27330
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (2 entities in total)
Functional Keywords	phosphoinositide 3-kinase (pi3k), activation, inhibition, nanobody, conformational changes, structural protein, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	211445.78
Authors	Hart, J.R.,Liu, X.,Pan, C.,Liang, A.,Ueno, L.,Xu, Y.,Quezada, A.,Zou, X.,Yang, S.,Zhou, Q.,Schoonooghe, S.,Hassanzadeh-Ghassabeh, G.,Xia, T.,Shui, W.,Yang, D.,Vogt, P.K.,Wang, M.-W. (deposition date: 2022-06-17, release date: 2022-09-21)
Primary citation	Hart, J.R.,Liu, X.,Pan, C.,Liang, A.,Ueno, L.,Xu, Y.,Quezada, A.,Zou, X.,Yang, S.,Zhou, Q.,Schoonooghe, S.,Hassanzadeh-Ghassabeh, G.,Xia, T.,Shui, W.,Yang, D.,Vogt, P.K.,Wang, M.W. Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119:e2210769119-e2210769119, 2022 Cited by PubMed: 36095215 DOI: 10.1073/pnas.2210769119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.8 Å)

Structure validation