5W3N
| Molecular structure of FUS low sequence complexity domain protein fibrils | Descriptor: | RNA-binding protein FUS | Authors: | Murray, D.T, Kato, M, Lin, Y, Thurber, K, Hung, I, McKnight, S, Tycko, R. | Deposit date: | 2017-06-08 | Release date: | 2017-09-27 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains. Cell, 171, 2017
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5WJK
| 2.0-Angstrom In situ Mylar structure of sperm whale myoglobin (SWMb) at 293 K | Descriptor: | CHLORIDE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Broecker, J, Ou, W.-L, Ernst, O.P. | Deposit date: | 2017-07-23 | Release date: | 2017-12-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions. Nat Protoc, 13, 2018
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8OW0
| Cryo-EM structure of CBF1-CCAN bound topologically to a centromeric CENP-A nucleosome | Descriptor: | C0N3 DNA, Centromere-binding protein 1, Histone H2A.1, ... | Authors: | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | Deposit date: | 2023-04-26 | Release date: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
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8OX1
| Structure of TRF1core in complex with telomeric nucleosome | Descriptor: | Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, Histone H3.1, ... | Authors: | Hu, H, van Roon, A.M.M, Ghanim, G.E, Ahsan, B, Oluwole, A, Peak-Chew, S, Robinson, C.V, Nguyen, T.H.D. | Deposit date: | 2023-04-28 | Release date: | 2023-08-30 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis of telomeric nucleosome recognition by shelterin factor TRF1. Sci Adv, 9, 2023
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5WLC
| The complete structure of the small subunit processome | Descriptor: | 18S pre-rRNA, 5' ETS, Bms1, ... | Authors: | Barandun, J, Chaker-Margot, M, Hunziker, M, Klinge, S. | Deposit date: | 2017-07-26 | Release date: | 2017-09-27 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The complete structure of the small-subunit processome. Nat. Struct. Mol. Biol., 24, 2017
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5WWO
| Crystal structure of Enp1 | Descriptor: | Essential nuclear protein 1, Protein LTV1 | Authors: | Ye, K, Zhang, W. | Deposit date: | 2017-01-03 | Release date: | 2017-06-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular architecture of the 90S small subunit pre-ribosome Elife, 6, 2017
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8OUE
| The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in a semi-closed conformation | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | Authors: | Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D. | Deposit date: | 2023-04-22 | Release date: | 2024-01-31 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | 2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein. Nat Commun, 15, 2024
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8OUF
| The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in an open conformation | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | Authors: | Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D. | Deposit date: | 2023-04-22 | Release date: | 2024-01-31 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | 2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein. Nat Commun, 15, 2024
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8OJ0
| 60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native) | Descriptor: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. | Deposit date: | 2023-03-23 | Release date: | 2024-02-21 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. Nature, 627, 2024
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5XSG
| Ultrahigh resolution structure of FUS (37-42) SYSGYS determined by MicroED | Descriptor: | RNA-binding protein FUS | Authors: | Luo, F, Gui, X, Zhou, H, Li, D, Li, X, Liu, C. | Deposit date: | 2017-06-14 | Release date: | 2018-04-04 | Last modified: | 2024-03-27 | Method: | ELECTRON CRYSTALLOGRAPHY (0.73 Å) | Cite: | Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nat. Struct. Mol. Biol., 25, 2018
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8QFC
| UFL1 E3 ligase bound 60S ribosome | Descriptor: | 60S ribosomal protein L10a, CDK5 regulatory subunit-associated protein 3, DDRGK domain-containing protein 1, ... | Authors: | Makhlouf, L, Zeqiraj, E, Kulathu, Y. | Deposit date: | 2023-09-04 | Release date: | 2024-02-21 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons. Nature, 627, 2024
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8R1G
| Dimeric ternary structure of E6AP-E6-p53 | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Monomeric E6AP-E6-p53 ternary complex To Be Published
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8R1F
| Monomeric E6AP-E6-p53 ternary complex | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Monomeric E6AP-E6-p53 ternary complex To Be Published
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8R62
| Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition | Descriptor: | 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-1~{H}-pyrido[1,2-a]pyrimidin-4-one, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') | Authors: | Malard, F, Campagne, S. | Deposit date: | 2023-11-20 | Release date: | 2024-03-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design. Nucleic Acids Res., 52, 2024
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8R8P
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8R63
| Solution structure of branaplam bound to the RNA duplex formed upon 5'-splice site recognition | Descriptor: | 5-(1~{H}-pyrazol-4-yl)-2-[6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridazin-3-yl]phenol, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') | Authors: | Malard, F, Campagne, S. | Deposit date: | 2023-11-20 | Release date: | 2024-03-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design. Nucleic Acids Res., 52, 2024
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5YVG
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5YZ0
| Cryo-EM Structure of human ATR-ATRIP complex | Descriptor: | ATR-interacting protein, Serine/threonine-protein kinase ATR | Authors: | Rao, Q, Liu, M, Tian, Y, Wu, Z, Wang, H, Wang, J, Xu, Y. | Deposit date: | 2017-12-11 | Release date: | 2018-01-31 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Cryo-EM structure of human ATR-ATRIP complex. Cell Res., 28, 2018
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2HDP
| Solution Structure of Hdm2 RING Finger Domain | Descriptor: | Ubiquitin-protein ligase E3 Mdm2, ZINC ION | Authors: | Kostic, M, Matt, T, Yamout-Martinez, M, Dyson, H.J, Wright, P.E. | Deposit date: | 2006-06-20 | Release date: | 2006-11-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J.Mol.Biol., 363, 2006
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2JQL
| NMR structure of the yeast Dun1 FHA domain in complex with a doubly phosphorylated (pT) peptide derived from Rad53 SCD1 | Descriptor: | DNA damage response protein kinase DUN1, Serine/threonine-protein kinase RAD53 | Authors: | Yuan, C, Lee, H, Chang, C, Heierhorst, J, Tsai, M. | Deposit date: | 2007-06-02 | Release date: | 2008-06-24 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol.Cell, 30, 2008
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2JQJ
| NMR structure of yeast Dun1 FHA domain | Descriptor: | DNA damage response protein kinase DUN1 | Authors: | Yuan, C, Lee, H, Chang, C, Heierhorst, J, Tsai, M. | Deposit date: | 2007-06-02 | Release date: | 2008-06-24 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol.Cell, 30, 2008
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2JQI
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2JAU
| Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase (mdN) in complex with 3'-azidothymidine 5'- monophosphate | Descriptor: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, 5'(3')-DEOXYRIBONUCLEOTIDASE, MAGNESIUM ION, ... | Authors: | Wallden, K, Ruzzenente, B, Bianchi, V, Nordlund, P. | Deposit date: | 2006-11-30 | Release date: | 2007-12-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Human and Murine Deoxyribonucleotidases: Insights Into Recognition of Substrates and Nucleotide Analogues. Biochemistry, 46, 2007
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2K8F
| Structural Basis for the Regulation of p53 Function by p300 | Descriptor: | Cellular tumor antigen p53, Histone acetyltransferase p300 | Authors: | Bai, Y, Feng, H, Jenkins, L.M, Durell, S.R, Wiodawer, A, Appella, E. | Deposit date: | 2008-09-08 | Release date: | 2009-03-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation. Structure, 17, 2009
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2L14
| Structure of CBP nuclear coactivator binding domain in complex with p53 TAD | Descriptor: | CREB-binding protein, Cellular tumor antigen p53 | Authors: | Lee, C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2010-07-22 | Release date: | 2010-11-03 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein. Biochemistry, 49, 2010
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