8CG9

Crystal structure of human DNA cross-link repair 1A in complex with a cyclic N-hydroxyurea inhibitor

Summary for 8CG9

• Entry DOI: 10.2210/pdb8cg9/pdb
• Descriptor: DNA cross-link repair 1A protein, NICKEL (II) ION, 1-[[(3~{R})-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-oxidanyl-thieno[3,2-d]pyrimidine-2,4-dione, ... (7 entities in total)
• Functional Keywords: dna cross link repair, nuclease inhibition, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 40025.16

Authors

Newman, J.A.,Yosaatmadja, Y.,Baddock, H.T.,Bielinski, M.,von Delft, F.,Bountra, C.,McHugh, P.J.,Schofield, C.J.,Gileadi, O. (deposition date: 2023-02-03, release date: 2024-02-21)

• Primary citation: Newman, J.A.,Yosaatmadja, Y.,Baddock, H.T.,Bielinski, M.,von Delft, F.,Bountra, C.,McHugh, P.J.,Schofield, C.J.,Gileadi, O.; Crystal structure of human DNA cross-link repair 1A in complex with a cyclic N-hydroxyurea inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.68 Å)