2ABJ

Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate.

Summary for 2ABJ

• Entry DOI: 10.2210/pdb2abj/pdb
• Descriptor: Branched-chain-amino-acid aminotransferase, cytosolic, N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• Functional Keywords: branched-chain-amino-acid aminotransferase, cytosolic, pyridoxal-phosphate-dependent aminotransferase, plp-lys220 schiff base, inhibitor-bound, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P54687
• Total number of polymer chains: 4
• Total formula weight: 167079.43

Authors

Ohren, J.F.,Moreland, D.W.,Rubin, J.R.,Hu, H.L.,McConnell, P.C.,Mistry, A.,Mueller, W.T.,Scholten, J.D.,Hasemann, C.H. (deposition date: 2005-07-15, release date: 2006-06-27, Last modification date: 2017-10-11)

• Primary citation: Hu, L.Y.,Boxer, P.A.,Kesten, S.R.,Lei, H.J.,Wustrow, D.J.,Moreland, D.W.,Zhang, L.,Ahn, K.,Ryder, T.R.,Liu, X.,Rubin, J.R.,Fahnoe, K.,Carroll, R.T.,Dutta, S.,Fahnoe, D.C.,Probert, A.W.,Roof, R.L.,Rafferty, M.F.,Kostlan, C.R.,Scholten, J.D.,Hood, M.,Ren, X.D.,Schielke, G.P.,Su, T.Z.,Taylor, C.P.,Mistry, A.,McConnell, P.,Hasemann, C.,Ohren, J.; The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.; Bioorg.Med.Chem.Lett., 16:2337-2340, 2006; PubMed: 16143519; DOI: 10.1016/j.bmcl.2005.07.058

Experimental method

X-RAY DIFFRACTION (2.2 Å)