2ABJ
Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, G, J) | Branched-chain-amino-acid aminotransferase, cytosolic | polymer | 366 | 41103.9 | 4 | UniProt (P54687) Pfam (PF01063) | Homo sapiens (human) | BCATc, ECA39 protein |
| 2 | E, G, I, K (A, D, G, J) | N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE | non-polymer | 418.8 | 4 | Chemie (CBC) | |||
| 3 | F, H, J, L (A, D, G, J) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 4 | Chemie (PLP) | |||
| 4 | M, N, O, P (A, D, G, J) | water | water | 18.0 | 1413 | Chemie (HOH) |
Sequence modifications
A, D, G, J: 19 - 384 (UniProt: P54687)
| PDB | External Database | Details |
|---|---|---|
| Ala 163 | Thr 165 | variant |
| Asp 235 | Ala 237 | variant |
| Arg 249 | Glu 251 | variant |
| Thr 315 | Ser 317 | variant |
| Ser 328 | Gly 330 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164415.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2663.7 | |
| All* | Total formula weight | 167079.4 |
