3G8I

Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of type II diabetes

Summary for 3G8I

• Entry DOI: 10.2210/pdb3g8i/pdb
• Related: 3G9E
• Descriptor: Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid, ... (4 entities in total)
• Functional Keywords: nuclear hormone receptor, transcription factor, diabetes, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription/transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: Q07869; Nucleus (By similarity): Q15788
• Total number of polymer chains: 2
• Total formula weight: 32670.12

Authors

Benz, J.,Bernardeau, A.,Binggeli, A.,Blum, D.,Boehringer, M.,Grether, U.,Hilpert, H.,Kuhn, B.,Maerki, H.P.,Meyer, M.,Puentener, K.,Raab, S.,Ruf, A.,Schlatter, D.,Gsell, B.,Stihle, M.,Mohr, P. (deposition date: 2009-02-12, release date: 2009-06-02, Last modification date: 2023-11-01)

Primary citation

Benardeau, A.,Benz, J.,Binggeli, A.,Blum, D.,Boehringer, M.,Grether, U.,Hilpert, H.,Kuhn, B.,Marki, H.P.,Meyer, M.,Puntener, K.,Raab, S.,Ruf, A.,Schlatter, D.,Mohr, P.
Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg.Med.Chem.Lett., 19:2468-2473, 2009

PubMed Abstract: Design, synthesis, and SAR of novel alpha-alkoxy-beta-arylpropionic acids as potent and balanced PPARalphagamma coagonists are described. One representative thereof, Aleglitazar ((S)-2Aa), was chosen for clinical development. Its X-ray structure in complex with both receptors as well as its high efficacy in animal models of T2D and dyslipidemia are also presented.

PubMed: 19349176
DOI: 10.1016/j.bmcl.2009.03.036

Experimental method

X-RAY DIFFRACTION (2.2 Å)