3G9E

Aleglitaar. a new. potent, and balanced dual ppara/g agonist for the treatment of type II diabetes

Summary for 3G9E

Related3G8I
DescriptorPeroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription factor, diabetes, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription/transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus P37231
Nucleus (By similarity) Q15788
Total number of polymer chains2
Total molecular weight32906.23
Authors
Primary citation
Benardeau, A.,Benz, J.,Binggeli, A.,Blum, D.,Boehringer, M.,Grether, U.,Hilpert, H.,Kuhn, B.,Marki, H.P.,Meyer, M.,Puntener, K.,Raab, S.,Ruf, A.,Schlatter, D.,Mohr, P.
Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg.Med.Chem.Lett., 19:2468-2473, 2009
PubMed: 19349176 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2009.03.036
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.233130.8%3.3%6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report