4HRA

Crystal Structure of DOT1L in Complex with EPZ-5676

Summary for 4HRA

• Entry DOI: 10.2210/pdb4hra/pdb
• Related: 3QOW 3QOX 4EK9 4EKG 4EKI
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, 5'-[{cis-3-[2-(5-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl}(propan-2-yl)amino]-5'-deoxyadenosine, SULFATE ION (3 entities in total)
• Functional Keywords: histone lysine methyltransferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q8TEK3
• Total number of polymer chains: 1
• Total formula weight: 49321.07

Authors

Jin, L. (deposition date: 2012-10-26, release date: 2013-07-31, Last modification date: 2023-09-20)

• Primary citation: Daigle, S.R.,Olhava, E.J.,Therkelsen, C.A.,Basavapathruni, A.,Jin, L.,Boriack-Sjodin, P.A.,Allain, C.J.,Klaus, C.R.,Raimondi, A.,Scott, M.P.,Waters, N.J.,Chesworth, R.,Moyer, M.P.,Copeland, R.A.,Richon, V.M.,Pollock, R.M.; Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.; Blood, 122:1017-1025, 2013; PubMed: 23801631; DOI: 10.1182/blood-2013-04-497644

Experimental method

X-RAY DIFFRACTION (3.15 Å)