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4HRA

Crystal Structure of DOT1L in Complex with EPZ-5676

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE EP6 A 501
ChainResidue
AASP161
AASP222
APHE223
APHE239
AASN241
AGLY163
ASER164
AGLY165
AVAL169
AVAL185
AGLU186
ALYS187
AGLY221

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 502
ChainResidue
AASN99
AARG101
ALYS212

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 503
ChainResidue
AHIS251
AASP286
AILE287

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues11
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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