3CJO
Crystal structure of KSP in complex with inhibitor 30
Summary for 3CJO
Entry DOI | 10.2210/pdb3cjo/pdb |
Descriptor | Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | ksp, ksp-inhibitor complex, atp-binding, cell cycle, cell division, coiled coil, microtubule, mitosis, motor protein, nucleotide-binding, phosphoprotein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 2 |
Total formula weight | 83670.79 |
Authors | |
Primary citation | Cox, C.D.,Coleman, P.J.,Breslin, M.J.,Whitman, D.B.,Garbaccio, R.M.,Fraley, M.E.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Schaber, M.D.,Lobell, R.B.,Tao, W.,Davide, J.P.,Diehl, R.E.,Abrams, M.T.,South, V.J.,Huber, H.E.,Torrent, M.,Prueksaritanont, T.,Li, C.,Slaughter, D.E.,Mahan, E.,Fernandez-Metzler, C.,Yan, Y.,Kuo, L.C.,Kohl, N.E.,Hartman, G.D. Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. J.Med.Chem., 51:4239-4252, 2008 Cited by PubMed: 18578472DOI: 10.1021/jm800386y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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