2Y3P

Crystal structure of N-terminal domain of GyrA with the antibiotic simocyclinone D8

Replaces:  2WL2

Summary for 2Y3P

• Entry DOI: 10.2210/pdb2y3p/pdb
• Descriptor: DNA GYRASE SUBUNIT A, MAGNESIUM ION, SIMOCYCLINONE D8, ... (4 entities in total)
• Functional Keywords: isomerase, aminocoumarin antibiotic
• Biological source: ESCHERICHIA COLI
• Cellular location: Cytoplasm : P0AES5
• Total number of polymer chains: 2
• Total formula weight: 119207.82

Authors

Edwards, M.J.,Flatman, R.H.,Mitchenall, L.A.,Stevenson, C.E.M.,Le, T.B.K.,Clarke, T.A.,McKay, A.R.,Fiedler, H.-P.,Buttner, M.J.,Lawson, D.M.,Maxwell, A. (deposition date: 2010-12-22, release date: 2010-12-29, Last modification date: 2023-12-20)

• Primary citation: Edwards, M.J.,Flatman, R.H.,Mitchenall, L.A.,Stevenson, C.E.M.,Le, T.B.K.,Clarke, T.A.,Mckay, A.R.,Fiedler, H.-P.,Buttner, M.J.,Lawson, D.M.,Maxwell, A.; A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase.; Science, 326:1415-, 2009; PubMed: 19965760; DOI: 10.1126/SCIENCE.1179123

Experimental method

X-RAY DIFFRACTION (2.62 Å)