2VCJ

4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

Summary for 2VCJ

Related2CDD 1UY9 1UY6 1BYQ 2BSM 1OSF 1YC4 1UY8 2BUG 2UWD 2C2L 1UYK 1UYH 2CCT 2BT0 1UYG 1UYE 1UYL 2CCU 2BZ5 1YC1 2CCS 1UYC 1UY7 1YC3 1UYF 1UYI 2BYH 1UYD 2BYI 2VCI
DescriptorHEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide (3 entities in total)
Functional Keywordsalternative splicing, atp-binding, phosphorylation, cytoplasm, chaperone, stress response, nucleotide-binding
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus  P07900
Total number of polymer chains1
Total molecular weight27059.68
Authors
Primary citation
Brough, P.A.,Aherne, W.,Barril, X.,Borgognoni, J.,Boxall, K.,Cansfield, J.E.,Cheung, K.M.,Collins, I.,Davies, N.G.,Drysdale, M.J.,Dymock, B.,Eccles, S.A.,Finch, H.,Fink, A.,Hayes, A.,Howes, R.,Hubbard, R.E.,James, K.,Jordan, A.M.,Lockie, A.,Martins, V.,Massey, A.,Matthews, T.P.,McDonald, E.,Northfield, C.J.,Pearl, L.H.,Prodromou, C.,Ray, S.,Raynaud, F.I.,Roughley, S.D.,Sharp, S.Y.,Surgenor, A.,Walmsley, D.L.,Webb, P.,Wood, M.,Workman, P.,Wright, L.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J. Med. Chem., 51:196-218, 2008
PubMed: 18020435 (PDB entries with the same primary citation)
DOI: 10.1021/jm701018h
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers111.0%5.6%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2vcj.pdb1.gz [73.69 KB])