2BZ5
Structure-based Discovery of a New Class of Hsp90 Inhibitors
Summary for 2BZ5
| Entry DOI | 10.2210/pdb2bz5/pdb |
| Related | 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BYH 2BYI |
| Descriptor | HEAT SHOCK PROTEIN HSP90-ALPHA, 2,5-DICHLORO-N-[4-HYDROXY-3-(2-HYDROXY-1-NAPHTHYL)PHENYL]BENZENESULFONAMIDE (3 entities in total) |
| Functional Keywords | atp-binding, chaperone, heat shock, nucleotide-binding, phosphorylation |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Nucleus : P07900 |
| Total number of polymer chains | 2 |
| Total formula weight | 53861.82 |
| Authors | Barril, X.,Brough, P.,Drysdale, M.,Hubbard, R.E.,Massey, A.,Surgenor, A.,Wright, L. (deposition date: 2005-08-11, release date: 2005-10-12, Last modification date: 2023-12-13) |
| Primary citation | Barril, X.,Brough, P.,Drysdale, M.,Hubbard, R.E.,Massey, A.,Surgenor, A.,Wright, L. Structure-Based Discovery of a New Class of Hsp90 Inhibitors. Bioorg.Med.Chem.Lett., 15:5187-, 2005 Cited by PubMed: 16202589DOI: 10.1016/J.BMCL.2005.08.092 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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