Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles

Summary for 1YC3

Related1YC1 1YC4
DescriptorHeat shock protein HSP 90-alpha, 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID (3 entities in total)
Functional Keywordscell-cycle, cancer, drug design, cell cycle
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P07900
Total number of polymer chains1
Total molecular weight30178.62
Kreusch, A.,Han, S.,Brinker, A.,Zhou, V.,Choi, H.,He, Y.,Lesley, S.A.,Caldwell, J.,Gu, X. (deposition date: 2004-12-21, release date: 2005-02-22, Last modification date: 2011-07-13)
Primary citation
Kreusch, A.,Han, S.,Brinker, A.,Zhou, V.,Choi, H.S.,He, Y.,Lesley, S.A.,Caldwell, J.,Gu, X.J.
Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Bioorg.Med.Chem.Lett., 15:1475-1478, 2005
PubMed: 15713410 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2004.12.087
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.201140.5%4.3%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution