1YC3
Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Heat shock protein HSP 90-alpha | polymer | 264 | 29810.3 | 1 | UniProt (P07900) Pfam (PF13589) In PDB | Homo sapiens (human) | HSP 86, ATP binding domain of HSP90 alpha |
| 2 | A | 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID | non-polymer | 368.3 | 1 | Chemie (4BC) | |||
| 3 | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A: 9 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Met -27 | - | cloning artifact |
| Arg -26 | - | cloning artifact |
| Gly -25 | - | cloning artifact |
| Ser -24 | - | cloning artifact |
| His -23 | - | cloning artifact |
| His -22 | - | cloning artifact |
| His -21 | - | cloning artifact |
| His -20 | - | cloning artifact |
| His -19 | - | cloning artifact |
| His -18 | - | cloning artifact |
| Gly -17 | - | cloning artifact |
| Met -16 | - | cloning artifact |
| Ala -15 | - | cloning artifact |
| Ser -14 | - | cloning artifact |
| Met -13 | - | cloning artifact |
| Thr -12 | - | cloning artifact |
| Gly -11 | - | cloning artifact |
| Gly -10 | - | cloning artifact |
| Gln -9 | - | cloning artifact |
| Gln -8 | - | cloning artifact |
| Met -7 | - | cloning artifact |
| Gly -6 | - | cloning artifact |
| Arg -5 | - | cloning artifact |
| Asp -4 | - | cloning artifact |
| Leu -3 | - | cloning artifact |
| Tyr -2 | - | cloning artifact |
| Asp -1 | - | cloning artifact |
| Asp 0 | - | cloning artifact |
| Asp 1 | - | cloning artifact |
| Asp 2 | - | cloning artifact |
| Lys 3 | - | cloning artifact |
| Asp 4 | - | cloning artifact |
| Arg 5 | - | cloning artifact |
| Trp 6 | - | cloning artifact |
| Gly 7 | - | cloning artifact |
| Ser 8 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29810.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 368.3 | |
| All* | Total formula weight | 30178.6 |
