1YC4
Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles
Summary for 1YC4
Entry DOI | 10.2210/pdb1yc4/pdb |
Related | 1yc1 1yc3 |
Descriptor | Heat shock protein HSP 90-alpha, 4-(1H-IMIDAZOL-4-YL)-3-(5-ETHYL-2,4-DIHYDROXY-PHENYL)-1H-PYRAZOLE (3 entities in total) |
Functional Keywords | cell-cycle, cancer, drug design, cell cycle |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 30080.57 |
Authors | Kreusch, A.,Han, S.,Brinker, A.,Zhou, V.,Choi, H.,He, Y.,Lesley, S.A.,Caldwell, J.,Gu, X. (deposition date: 2004-12-21, release date: 2005-02-22, Last modification date: 2024-02-14) |
Primary citation | Kreusch, A.,Han, S.,Brinker, A.,Zhou, V.,Choi, H.S.,He, Y.,Lesley, S.A.,Caldwell, J.,Gu, X.J. Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles. Bioorg.Med.Chem.Lett., 15:1475-1478, 2005 Cited by PubMed: 15713410DOI: 10.1016/j.bmcl.2004.12.087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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