1YC4

Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles

Summary for 1YC4

• Entry DOI: 10.2210/pdb1yc4/pdb
• Related: 1yc1 1yc3
• Descriptor: Heat shock protein HSP 90-alpha, 4-(1H-IMIDAZOL-4-YL)-3-(5-ETHYL-2,4-DIHYDROXY-PHENYL)-1H-PYRAZOLE (3 entities in total)
• Functional Keywords: cell-cycle, cancer, drug design, cell cycle
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 1
• Total formula weight: 30080.57

Authors

Kreusch, A.,Han, S.,Brinker, A.,Zhou, V.,Choi, H.,He, Y.,Lesley, S.A.,Caldwell, J.,Gu, X. (deposition date: 2004-12-21, release date: 2005-02-22, Last modification date: 2024-02-14)

• Primary citation: Kreusch, A.,Han, S.,Brinker, A.,Zhou, V.,Choi, H.S.,He, Y.,Lesley, S.A.,Caldwell, J.,Gu, X.J.; Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.; Bioorg.Med.Chem.Lett., 15:1475-1478, 2005; PubMed: 15713410; DOI: 10.1016/j.bmcl.2004.12.087

Experimental method

X-RAY DIFFRACTION (1.81 Å)