1UY6

Human Hsp90-alpha with 9-Butyl-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine

Summary for 1UY6

Related1BYQ 1OSF 1YER 1YES 1YET 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1UYM
DescriptorHEAT SHOCK PROTEIN HSP 90-ALPHA, 9-BUTYL-8-(3,4,5-TRIMETHOXYBENZYL)-9H-PURIN-6-AMINE (3 entities in total)
Functional Keywordshsp90, atpase, pu3, chaperone, atp-binding, heat shock
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P07900
Total number of polymer chains1
Total molecular weight26973.21
Authors
Primary citation
Wright, L.,Barril, X.,Dymock, B.,Sheridan, L.,Surgenor, A.,Beswick, M.,Drysdale, M.,Collier, A.,Massey, A.,Davies, N.,Fink, A.,Fromont, C.,Aherne, W.,Boxall, K.,Sharp, S.,Workman, P.,Hubbard, R.E.
Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11:775-, 2004
PubMed: 15217611 (PDB entries with the same primary citation)
DOI: 10.1016/J.CHEMBIOL.2004.03.033
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23630.5%1.1%6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution