1OSF

Human Hsp90 in complex with 17-desmethoxy-17-N,N-Dimethylaminoethylamino-Geldanamycin

Summary for 1OSF

Descriptorheat shock 90kDa protein 1, alpha; heat shock 90kD protein 1, alpha, 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
Functional Keywordscell cycle
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P07900
Total number of polymer chains1
Total molecular weight25095.41
Authors
Jez, J.M.,Chen, J.C.-H.,Rastelli, G.,Stroud, R.M.,Santi, D.V. (deposition date: 2003-03-19, release date: 2003-05-27, Last modification date: 2011-07-13)
Primary citation
Jez, J.M.,Chen, J.C.,Rastelli, G.,Stroud, R.M.,Santi, D.V.
Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp90
Chem.Biol., 10:361-368, 2003
PubMed: 12725864 (PDB entries with the same primary citation)
DOI: 10.1016/S1074-5521(03)00075-9
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.75 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1002.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution