2BZ5
Structure-based Discovery of a New Class of Hsp90 Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HEAT SHOCK PROTEIN HSP90-ALPHA | polymer | 235 | 26470.6 | 2 | UniProt (P07900) Pfam (PF13589) | HOMO SAPIENS (HUMAN) | HSP 86 |
| 2 | C, D (A, B) | 2,5-DICHLORO-N-[4-HYDROXY-3-(2-HYDROXY-1-NAPHTHYL)PHENYL]BENZENESULFONAMIDE | non-polymer | 460.3 | 2 | Chemie (AB4) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 499 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Ser 63 | Thr 62 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52941.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 920.7 | |
| All* | Total formula weight | 53861.8 |
