2CCU

HUMAN HSP90 WITH 4-CHLORO-6-(4-(4-(4-METHANESULPHONYL-BENZYL)- PIERAZIN-1-YL)-1H-PYRAZOL-3-YL)-BENZENE-1,3-DIOL

Summary for 2CCU

• Entry DOI: 10.2210/pdb2ccu/pdb
• Related: 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT
• Descriptor: HEAT SHOCK PROTEIN HSP-90 ALPHA, 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL (3 entities in total)
• Functional Keywords: heat-shock protein-complex, hsp90, atpase, pyrazole, chaperone, atp-binding, heat shock, nucleotide-binding, phosphorylation
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : P07900
• Total number of polymer chains: 1
• Total formula weight: 27078.75

Authors

Barril, X.,Beswick, M.C.,Collier, A.,Drysdale, M.J.,Dymock, B.W.,Fink, A.,Grant, K.,Howes, R.,Jordan, A.M.,Massey, A.,Surgenor, A.,Wayne, J.,Workman, P.,Wright, L. (deposition date: 2006-01-18, release date: 2006-02-22, Last modification date: 2018-03-28)

• Primary citation: Barril, X.,Beswick, M.C.,Collier, A.,Drysdale, M.J.,Dymock, B.W.,Fink, A.,Grant, K.,Howes, R.,Jordan, A.M.,Massey, A.,Surgenor, A.,Wayne, J.,Workman, P.,Wright, L.; 4-Amino derivatives of the Hsp90 inhibitor CCT018159.; Bioorg. Med. Chem. Lett., 16:2543-2548, 2006; PubMed: 16480864; DOI: 10.1016/j.bmcl.2006.01.099

Experimental method

X-RAY DIFFRACTION (2.7 Å)