8TUA
 
 | | Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4) | | Descriptor: | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | | Authors: | Cash, J.N, Tesmer, J.J.G. | | Deposit date: | 2023-08-15 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)
Elife, 2024
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6PCV
 | | Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 | | Authors: | Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. | | Deposit date: | 2019-06-18 | | Release date: | 2019-10-23 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
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1NTY
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8BNT
 | | The DH domain of ARHGEF2 bound to RhoA | | Descriptor: | DIMETHYL SULFOXIDE, FORMIC ACID, Rho guanine nucleotide exchange factor 2, ... | | Authors: | Bradshaw, W.J, Katis, V.L, Grosjean, H, Bountra, C, von Delft, F, Brennan, P.E. | | Deposit date: | 2022-11-25 | | Release date: | 2022-12-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The DH domain of ARHGEF2 bound to RhoA
To Be Published
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3QBV
 | | Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin | | Descriptor: | Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, Intersectin-1 | | Authors: | Kapp, G.T, Remenyi, A, Lim, W.A, Kortemme, T. | | Deposit date: | 2011-01-14 | | Release date: | 2012-02-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.
Proc.Natl.Acad.Sci.USA, 109, 2012
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2DX1
 | | Crystal structure of RhoGEF protein Asef | | Descriptor: | Rho guanine nucleotide exchange factor 4 | | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-08-22 | | Release date: | 2007-01-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism
J.Biol.Chem., 282, 2007
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2RGN
 | | Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | | Authors: | Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. | | Deposit date: | 2007-10-04 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318, 2007
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4D0N
 | | AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA | | Descriptor: | 1,2-ETHANEDIOL, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. | | Deposit date: | 2014-04-29 | | Release date: | 2014-05-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
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5FI0
 | | Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 | | Descriptor: | PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 | | Authors: | Cash, J.N, Tesmer, J.J.G. | | Deposit date: | 2015-12-22 | | Release date: | 2016-04-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.282 Å) | | Cite: | Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
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4XH9
 | | CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR NET1 | | Descriptor: | Neuroepithelial cell-transforming gene 1 protein, Transforming protein RhoA | | Authors: | Garcia, C, Petit, P, Boutin, J.A, Ferry, G, Vuillard, L. | | Deposit date: | 2015-01-05 | | Release date: | 2015-01-14 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot.
J. Biol. Chem., 293, 2018
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5FI1
 | | Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 | | Descriptor: | Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | | Authors: | Cash, J.N, Tesmer, J.J.G. | | Deposit date: | 2015-12-22 | | Release date: | 2016-04-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.203 Å) | | Cite: | Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
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3BJI
 | | Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 | | Descriptor: | Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION | | Authors: | Chrencik, J.E, Brooun, A, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | | Deposit date: | 2007-12-04 | | Release date: | 2008-07-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
J.Mol.Biol., 380, 2008
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2VRW
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2NZ8
 | | N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 | | Descriptor: | ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein | | Authors: | Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J. | | Deposit date: | 2006-11-22 | | Release date: | 2007-04-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
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4YON
 | | P-Rex1:Rac1 complex | | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 | | Authors: | Lucato, C.M, Whisstock, J.C, Ellisdon, A.M. | | Deposit date: | 2015-03-11 | | Release date: | 2015-07-01 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J.Biol.Chem., 290, 2015
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3T06
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2PZ1
 | | Crystal Structure of Auto-inhibited Asef | | Descriptor: | Rho guanine nucleotide exchange factor 4 | | Authors: | Betts, L, Sondek, J, Rossman, K.L. | | Deposit date: | 2007-05-17 | | Release date: | 2007-08-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
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2DFK
 | | Crystal structure of the CDC42-Collybistin II complex | | Descriptor: | GLYCEROL, SULFATE ION, cell division cycle 42 isoform 1, ... | | Authors: | Xiang, S, Kim, E.Y, Connelly, J.J, Nassar, N, Kirsch, J, Winking, J, Schwarz, G, Schindelin, H. | | Deposit date: | 2006-03-02 | | Release date: | 2006-05-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor.
J.Mol.Biol., 359, 2006
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7SJ4
 | | Human Trio residues 1284-1959 in complex with Rac1 | | Descriptor: | Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein | | Authors: | Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G. | | Deposit date: | 2021-10-15 | | Release date: | 2022-07-06 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
J.Biol.Chem., 298, 2022
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7RX9
 | | Structure of autoinhibited P-Rex1 | | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION | | Authors: | Ellisdon, A.M, Chang, Y. | | Deposit date: | 2021-08-22 | | Release date: | 2022-08-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat.Struct.Mol.Biol., 29, 2022
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1FOE
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6NFA
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7SYF
 | | Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1) | | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera | | Authors: | Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M. | | Deposit date: | 2021-11-24 | | Release date: | 2022-07-27 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat.Struct.Mol.Biol., 29, 2022
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6NEW
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7CSP
 | | Structure of Ephexin4 IDPSH | | Descriptor: | Rho guanine nucleotide exchange factor 16 | | Authors: | Zhang, M, Lin, L, Wang, C, Zhu, J. | | Deposit date: | 2020-08-15 | | Release date: | 2021-02-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Double inhibition and activation mechanisms of Ephexin family RhoGEFs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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