7SYF
Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)
Summary for 7SYF
Entry DOI | 10.2210/pdb7syf/pdb |
EMDB information | 25524 25525 25526 |
Descriptor | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera (1 entity in total) |
Functional Keywords | guanine nucleotide exchange factor, metastasis, plasma membrane, rho gtpase signalling, oncoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 191462.98 |
Authors | Lupton, C.J.,Bayly-Jones, C.,Ellisdon, A.M. (deposition date: 2021-11-24, release date: 2022-07-27, Last modification date: 2024-02-28) |
Primary citation | Chang, Y.G.,Lupton, C.J.,Bayly-Jones, C.,Keen, A.C.,D'Andrea, L.,Lucato, C.M.,Steele, J.R.,Venugopal, H.,Schittenhelm, R.B.,Whisstock, J.C.,Halls, M.L.,Ellisdon, A.M. Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29:767-773, 2022 Cited by PubMed: 35864164DOI: 10.1038/s41594-022-00804-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.2 Å) |
Structure validation
Download full validation report