4XH9

CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR NET1

Summary for 4XH9

Entry DOI	10.2210/pdb4xh9/pdb
Descriptor	Neuroepithelial cell-transforming gene 1 protein, Transforming protein RhoA (3 entities in total)
Functional Keywords	rhoa gtpase, signaling protein, activator, guanine nucleotide exchange factor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	125043.09
Authors	Garcia, C.,Petit, P.,Boutin, J.A.,Ferry, G.,Vuillard, L. (deposition date: 2015-01-05, release date: 2015-01-14, Last modification date: 2024-01-10)
Primary citation	Petit, A.P.,Garcia-Petit, C.,Bueren-Calabuig, J.A.,Vuillard, L.M.,Ferry, G.,Boutin, J.A. A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot. J. Biol. Chem., 293:9064-9077, 2018 Cited by PubMed: 29695506 DOI: 10.1074/jbc.RA117.001123 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation