3QBV
Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin
Summary for 3QBV
Entry DOI | 10.2210/pdb3qbv/pdb |
Related | 1KI1 |
Descriptor | Cell division control protein 42 homolog, Intersectin-1, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | computationally designed, orthogonal interaction, gtpase, nucleotide exchange, cell membrane, gtp-binding, lipoprotein, membrane, methylation, nucleotide-binding, prenylation, cell junction, cell projection, endocytosis, phosphoprotein, sh3 domain, synapse, synaptosome, protein binding-signaling protein complex, protein binding/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P60953 Endomembrane system (By similarity): Q15811 |
Total number of polymer chains | 4 |
Total formula weight | 121928.46 |
Authors | Kapp, G.T.,Remenyi, A.,Lim, W.A.,Kortemme, T. (deposition date: 2011-01-14, release date: 2012-02-08, Last modification date: 2023-09-13) |
Primary citation | Kapp, G.T.,Liu, S.,Stein, A.,Wong, D.T.,Remenyi, A.,Yeh, B.J.,Fraser, J.S.,Taunton, J.,Lim, W.A.,Kortemme, T. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc.Natl.Acad.Sci.USA, 109:5277-5282, 2012 Cited by PubMed: 22403064DOI: 10.1073/pnas.1114487109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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