7RX9

Structure of autoinhibited P-Rex1

Summary for 7RX9

Entry DOI	10.2210/pdb7rx9/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION (2 entities in total)
Functional Keywords	p-rex1, p-rex2, gef, cell growth, rac1, cdc42, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	70603.07
Authors	Ellisdon, A.M.,Chang, Y. (deposition date: 2021-08-22, release date: 2022-08-10, Last modification date: 2023-10-18)
Primary citation	Chang, Y.G.,Lupton, C.J.,Bayly-Jones, C.,Keen, A.C.,D'Andrea, L.,Lucato, C.M.,Steele, J.R.,Venugopal, H.,Schittenhelm, R.B.,Whisstock, J.C.,Halls, M.L.,Ellisdon, A.M. Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29:767-773, 2022 Cited by PubMed: 35864164 DOI: 10.1038/s41594-022-00804-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.22 Å)

Structure validation