6NFA

Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity

Summary for 6NFA

• Entry DOI: 10.2210/pdb6nfa/pdb
• Related: 6NEW 6NF1
• Descriptor: Proto-oncogene vav, ZINC ION, (2S)-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}-3-(pyridin-3-yl)propan-1-ol, ... (4 entities in total)
• Functional Keywords: gef, rac, vav1, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 50170.12

Authors

Knapp, M.S.,Elling, R.A.,Ornelas, E. (deposition date: 2018-12-19, release date: 2019-12-25, Last modification date: 2023-10-11)

• Primary citation: Gerspacher, M.,Skaanderup, P.R.; Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)