6Q9L
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![BU of 6q9l by Molmil](/molmil-images/mine/6q9l) | |
4LWU
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![BU of 4lwu by Molmil](/molmil-images/mine/4lwu) | The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252 | 分子名称: | (2'S,3R,4'S,5'R)-N-(4-carbamoylphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Graves, B.J, Lukacs, C, Janson, C.A. | 登録日 | 2013-07-28 | 公開日 | 2014-07-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg.Med.Chem., 22, 2014
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5C5A
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![BU of 5c5a by Molmil](/molmil-images/mine/5c5a) | Crystal Structure of HDM2 in complex with Nutlin-3a | 分子名称: | 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... | 著者 | Orts, J, Waelti, M.A, Marsh, M, Vera, L, Gossert, A.D, Guentert, P, Riek, R. | 登録日 | 2015-06-19 | 公開日 | 2016-06-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.146 Å) | 主引用文献 | NMR Molecular Replacement, NMR2 To Be Published
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4J74
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![BU of 4j74 by Molmil](/molmil-images/mine/4j74) | The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment | 分子名称: | (4S,5R)-4,5-bis(4-chlorophenyl)-2-methyl-4,5-dihydro-1H-imidazole, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Janson, C, Lukacs, C, Kammlott, U, Graves, B. | 登録日 | 2013-02-12 | 公開日 | 2013-08-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor. ACS Med Chem Lett, 4, 2013
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6Q9O
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![BU of 6q9o by Molmil](/molmil-images/mine/6q9o) | |
6V4G
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![BU of 6v4g by Molmil](/molmil-images/mine/6v4g) | |
4J7D
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![BU of 4j7d by Molmil](/molmil-images/mine/4j7d) | The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331 | 分子名称: | (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Janson, C, Lukacs, C, Graves, B. | 登録日 | 2013-02-13 | 公開日 | 2013-08-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor. ACS Med Chem Lett, 4, 2013
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5ZXF
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![BU of 5zxf by Molmil](/molmil-images/mine/5zxf) | The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a | 分子名称: | 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2 | 著者 | Cheng, X.Y, Su, Z.D, Pi, N, Cao, C.Z, Zhao, Z.T, Zhou, J.J, Chen, R, Kuang, Z.K, Huang, Y.Q. | 登録日 | 2018-05-19 | 公開日 | 2018-08-22 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a To Be Published
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7QDQ
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![BU of 7qdq by Molmil](/molmil-images/mine/7qdq) | Crystal Structure of HDM2 in complex with Caylin-1 | 分子名称: | CHLORIDE ION, Caylin-1, DIMETHYL SULFOXIDE, ... | 著者 | Finke, A.D, Walti, M.A, Marsh, M.E, Orts, J. | 登録日 | 2021-11-29 | 公開日 | 2022-10-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Elucidation of a nutlin-derivative-HDM2 complex structure at the interaction site by NMR molecular replacement: A straightforward derivation J Magn Reson Open, 10-11, 2022
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8F10
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![BU of 8f10 by Molmil](/molmil-images/mine/8f10) | Structure of the MDM2 P53 binding domain in complex with H102, an all-D Helicon Polypeptide | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... | 著者 | Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. | 登録日 | 2022-11-04 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
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8EBK
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![BU of 8ebk by Molmil](/molmil-images/mine/8ebk) | |
6V4F
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![BU of 6v4f by Molmil](/molmil-images/mine/6v4f) | |
8J81
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![BU of 8j81 by Molmil](/molmil-images/mine/8j81) | MDM2 bound with a peptoid | 分子名称: | (2S)-2-[[(2S)-2-[(6-chloranyl-1H-indol-3-yl)methyl-[(2S)-2-[[(2S)-2-[ethanoyl-(phenylmethyl)amino]propanoyl]-methyl-amino]propanoyl]amino]propanoyl]-methyl-amino]-N-(3,3-dimethylbutyl)-N-[(2S)-1-oxidanylidene-1-piperazin-1-yl-propan-2-yl]propanamide, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2 | 著者 | Yokomine, M, Fukuda, Y, Ago, H, Matsuura, H, Ueno, G, Nagatoishi, S, Yamamoto, M, Tsumoto, K, Jumpei, M, Sando, S. | 登録日 | 2023-04-28 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | A structural and physicochemical study of how a peptoid binds to a protein To Be Published
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5Z02
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![BU of 5z02 by Molmil](/molmil-images/mine/5z02) | Crystal structure of HIS6-tagged Mdm2 with nutlin-3a | 分子名称: | 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2 | 著者 | Su, Z.D, Cheng, X.Y, Chen, R, Pi, N. | 登録日 | 2017-12-18 | 公開日 | 2018-01-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal structure of HIS6-tagged Mdm2 with nutlin-3a to be published
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4OGN
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![BU of 4ogn by Molmil](/molmil-images/mine/4ogn) | Co-Crystal Structure of MDM2 with Inhbitor Compound 3 | 分子名称: | 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-01-16 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.377 Å) | 主引用文献 | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
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8F13
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![BU of 8f13 by Molmil](/molmil-images/mine/8f13) | Structure of the MDM2 P53 binding domain in complex with H103, an all-D Helicon Polypeptide, alternative C-terminus | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, E3 ubiquitin-protein ligase Mdm2, ... | 著者 | Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. | 登録日 | 2022-11-04 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
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2AXI
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![BU of 2axi by Molmil](/molmil-images/mine/2axi) | HDM2 in complex with a beta-hairpin | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, ... | 著者 | Mittl, P.R.E, Fasan, R, Robinson, J, Gruetter, M.G. | 登録日 | 2005-09-05 | 公開日 | 2006-03-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction. Chembiochem, 7, 2006
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7KJM
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![BU of 7kjm by Molmil](/molmil-images/mine/7kjm) | |
4WT2
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![BU of 4wt2 by Molmil](/molmil-images/mine/4wt2) | Co-crystal Structure of MDM2 in Complex with AM-7209 | 分子名称: | 4-({[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl}amino)-2-methoxybenzoic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-10-30 | 公開日 | 2014-12-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction. J.Med.Chem., 57, 2014
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7NUS
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![BU of 7nus by Molmil](/molmil-images/mine/7nus) | |
4UE1
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![BU of 4ue1 by Molmil](/molmil-images/mine/4ue1) | Structure of the stapled peptide YS-01 bound to MDM2 | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE MDM2, YS-01 | 著者 | Tan, Y.S, Reeks, J, Brown, C.J, Jennings, C.E, Eapen, R.S, Tng, Q.S, Thean, D, Ying, Y.T, Gago, F.J.F, Lane, D.P, Noble, M.E.M, Verma, C. | 登録日 | 2014-12-14 | 公開日 | 2016-01-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design. J Phys Chem Lett, 7, 2016
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6V4H
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![BU of 6v4h by Molmil](/molmil-images/mine/6v4h) | |
4OGT
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![BU of 4ogt by Molmil](/molmil-images/mine/4ogt) | Co-Crystal Structure of MDM2 with Inhbitor Compound 46 | 分子名称: | 6-{[(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-01-16 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5361 Å) | 主引用文献 | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
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5OC8
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![BU of 5oc8 by Molmil](/molmil-images/mine/5oc8) | HDM2 (17-111, WILD TYPE) COMPLEXED WITH NVP-HDM201 AT 1.56A | 分子名称: | (4~{S})-5-(5-chloranyl-1-methyl-2-oxidanylidene-pyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-d]imidazol-6-one, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2 | 著者 | Kallen, J. | 登録日 | 2017-06-29 | 公開日 | 2018-08-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201. Cancer Res., 78, 2018
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5LN2
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![BU of 5ln2 by Molmil](/molmil-images/mine/5ln2) | |