5ZXF

The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a

Summary for 5ZXF

• Entry DOI: 10.2210/pdb5zxf/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one (3 entities in total)
• Functional Keywords: p53., cell cycle
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 10853.64

Authors

Cheng, X.Y.,Su, Z.D.,Pi, N.,Cao, C.Z.,Zhao, Z.T.,Zhou, J.J.,Chen, R.,Kuang, Z.K.,Huang, Y.Q. (deposition date: 2018-05-19, release date: 2018-08-22, Last modification date: 2024-03-27)

• Primary citation: Cheng, X.Y.,Su, Z.D.; The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.25 Å)