5ZXF
The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a
Summary for 5ZXF
Entry DOI | 10.2210/pdb5zxf/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one (3 entities in total) |
Functional Keywords | p53., cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 10853.64 |
Authors | Cheng, X.Y.,Su, Z.D.,Pi, N.,Cao, C.Z.,Zhao, Z.T.,Zhou, J.J.,Chen, R.,Kuang, Z.K.,Huang, Y.Q. (deposition date: 2018-05-19, release date: 2018-08-22, Last modification date: 2024-03-27) |
Primary citation | Cheng, X.Y.,Su, Z.D. The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
Download full validation report