5Z02

Crystal structure of HIS6-tagged Mdm2 with nutlin-3a

Summary for 5Z02

• Entry DOI: 10.2210/pdb5z02/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one (3 entities in total)
• Functional Keywords: inhibitor; e3-ligase, oncoprotein
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 1
• Total formula weight: 13538.39

Authors

Su, Z.D.,Cheng, X.Y.,Chen, R.,Pi, N. (deposition date: 2017-12-18, release date: 2018-01-03, Last modification date: 2023-11-22)

• Primary citation: Su, Z.D.,Cheng, X.Y.; Crystal structure of HIS6-tagged Mdm2 with nutlin-3a; to be published,

Experimental method

X-RAY DIFFRACTION (1.35 Å)