5Z02
Crystal structure of HIS6-tagged Mdm2 with nutlin-3a
Summary for 5Z02
Entry DOI | 10.2210/pdb5z02/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one (3 entities in total) |
Functional Keywords | inhibitor; e3-ligase, oncoprotein |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 1 |
Total formula weight | 13538.39 |
Authors | Su, Z.D.,Cheng, X.Y.,Chen, R.,Pi, N. (deposition date: 2017-12-18, release date: 2018-01-03, Last modification date: 2023-11-22) |
Primary citation | Su, Z.D.,Cheng, X.Y. Crystal structure of HIS6-tagged Mdm2 with nutlin-3a to be published, |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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