4LWU
The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252
Summary for 4LWU
Entry DOI | 10.2210/pdb4lwu/pdb |
Related | 4LWT 4LWV |
Descriptor | E3 ubiquitin-protein ligase Mdm2, (2'S,3R,4'S,5'R)-N-(4-carbamoylphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | mdm2, spiroindolinone, e3 ubiquitin ligase, p53, nucleus, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Xenopus laevis (clawed frog,common platanna,platanna) |
Cellular location | Nucleus, nucleoplasm (By similarity): P56273 |
Total number of polymer chains | 1 |
Total formula weight | 10510.96 |
Authors | Graves, B.J.,Lukacs, C.,Janson, C.A. (deposition date: 2013-07-28, release date: 2014-07-16, Last modification date: 2024-02-28) |
Primary citation | Zhang, Z.,Ding, Q.,Liu, J.J.,Zhang, J.,Jiang, N.,Chu, X.J.,Bartkovitz, D.,Luk, K.C.,Janson, C.,Tovar, C.,Filipovic, Z.M.,Higgins, B.,Glenn, K.,Packman, K.,Vassilev, L.T.,Graves, B. Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg.Med.Chem., 22:4001-4009, 2014 Cited by PubMed: 24997575DOI: 10.1016/j.bmc.2014.05.072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.14 Å) |
Structure validation
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