5JR2
 
 | | Crystal structure of the EphA4 LBD in complex with APYd3 peptide inhibitor | | 分子名称: | APYd3 peptide, Ephrin type-A receptor 4, GLYCEROL, ... | | 著者 | Lechtenberg, B.C, Olson, E.J, Pasquale, E.B, Dawson, P.E, Riedl, S.J. | | 登録日 | 2016-05-05 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.
Acs Med.Chem.Lett., 7, 2016
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9CY8
 | | Constrained b-hairpins targeting the EphA4 ligand binding domain | | 分子名称: | CHLORIDE ION, Constrained b-hairpin, Ephrin type-A receptor 4 | | 著者 | Muzzarelli, K.M, Assar, Z, Prentis, A.M, Baggio, C, Pellecchia, M. | | 登録日 | 2024-08-01 | | 公開日 | 2024-12-25 | | 最終更新日 | 2025-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Constrained beta-Hairpins Targeting the EphA4 Ligand Binding Domain.
J.Med.Chem., 67, 2024
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1NUK
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2BBA
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7OFV
 | | NMR-guided design of potent and selective EphA4 agonistic ligands | | 分子名称: | ACETATE ION, EphA4 agonist ligand, Ephrin type-A receptor 4 | | 著者 | Ganichkin, O.M, Craig, T.K, Baggio, C, Pellecchia, M. | | 登録日 | 2021-05-05 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
J.Med.Chem., 64, 2021
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2QBX
 | | EphB2/SNEW Antagonistic Peptide Complex | | 分子名称: | Ephrin type-B receptor 2, SULFATE ION, antagonistic peptide | | 著者 | Chrencik, J.E, Brooun, A, Recht, M.I, Nicola, G, Pasquale, E.B, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | | 登録日 | 2007-06-18 | | 公開日 | 2007-11-06 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.
J.Biol.Chem., 282, 2007
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3SKJ
 | | Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody | | 分子名称: | Antibody, heavy chain, light chain, ... | | 著者 | Oganesyan, V.Y, Wu, H, Dall'Acqua, W.F. | | 登録日 | 2011-06-22 | | 公開日 | 2011-08-31 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.
J.Mol.Biol., 413, 2011
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6RW2
 | | Bicycle Toxin Conjugate bound to EphA2 | | 分子名称: | 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, ALA-ARG-ASP-CYS-PRO-LEU-VAL-ASN-PRO-LEU-CYS-LEU-HIS-PRO-GLY-TRP-THR-CYS, Ephrin type-A receptor 2, ... | | 著者 | Brown, D.G, Schroeder, S, Chen, L. | | 登録日 | 2019-06-03 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads.
J.Med.Chem., 63, 2020
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4ET7
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2LW8
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6B9L
 | | Crystal structure of EphA2 with peptide 135E2 | | 分子名称: | Ephrin type-A receptor 2, HIS TAG CLEAVED OFF, peptide 135E2, ... | | 著者 | Song, J, Tan, X. | | 登録日 | 2017-10-10 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell.
ACS Chem. Biol., 13, 2018
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4W50
 | | Structure of the EphA4 LBD in complex with peptide | | 分子名称: | 1,3-BUTANEDIOL, APY peptide, Ephrin type-A receptor 4, ... | | 著者 | Lechtenberg, B.C, Mace, P.D, Riedl, S.J. | | 登録日 | 2014-08-16 | | 公開日 | 2014-10-08 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
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3NRU
 | | Ligand binding domain of EPHA7 | | 分子名称: | CHLORIDE ION, Ephrin receptor, SULFATE ION | | 著者 | Walker, J.R, Yermekbayeva, L, Seitova, A, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S. | | 登録日 | 2010-06-30 | | 公開日 | 2010-12-08 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Ephrin A7 ligand binding domain
To be Published
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4W4Z
 | | Structure of the EphA4 LBD in complex with peptide | | 分子名称: | APY-bAla8.am peptide, Ephrin type-A receptor 4, GLYCEROL, ... | | 著者 | Lechtenberg, B.C, Mace, P.D, Riedl, S.J. | | 登録日 | 2014-08-15 | | 公開日 | 2014-10-08 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
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3ETP
 | | The crystal structure of the ligand-binding domain of the EphB2 receptor at 2.0 A resolution | | 分子名称: | Ephrin type-B receptor 2 | | 著者 | Goldgur, Y, Paavilainen, S, Nikolov, D.B, Himanen, J.P. | | 登録日 | 2008-10-08 | | 公開日 | 2008-10-21 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution.
Acta Crystallogr.,Sect.F, 65, 2009
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3P1I
 | | Ligand binding domain of human ephrin type-B receptor 3 | | 分子名称: | CHLORIDE ION, Ephrin type-B receptor 3, SULFATE ION | | 著者 | Walker, J.R, Yermekbayeva, L, Seitova, A, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2010-09-30 | | 公開日 | 2011-01-19 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Ligand Binding Domain of Human Ephb3
To be Published
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3HPN
 | | Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain and the EPHA2/EPHRIN-A1 complex | | 分子名称: | Ephrin type-A receptor 2 | | 著者 | Himanen, J.P, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, K.R, Wang, B, Nikolov, D.B. | | 登録日 | 2009-06-04 | | 公開日 | 2009-06-30 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
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8TV1
 | | Structure of the EphA2 LBDCRD bound to FabS1C_L1 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Ephrin type-A receptor 2, ... | | 著者 | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | | 登録日 | 2023-08-17 | | 公開日 | 2024-06-26 | | 最終更新日 | 2025-06-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation.
Protein Sci., 34, 2025
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8TRV
 | | Structure of the EphA2 LBDCRD bound to FabS1C_C1 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Ephrin type-A receptor 2, ... | | 著者 | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | | 登録日 | 2023-08-10 | | 公開日 | 2024-07-17 | | 最終更新日 | 2025-06-04 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation.
Protein Sci., 34, 2025
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3C8X
 | | Crystal structure of the ligand binding domain of human Ephrin A2 (Epha2) receptor protein kinase | | 分子名称: | Ephrin type-A receptor 2 | | 著者 | Walker, J.R, Yermekbayeva, L, Seitova, A, Butler-Cole, C, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2008-02-14 | | 公開日 | 2008-03-25 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
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8TV5
 | | Structure of the EphA2 LBDCRD bound to FabS1CE_L1 in a 2:1 (EphA2 to Fab) ratio | | 分子名称: | Ephrin type-A receptor 2, MAGNESIUM ION, S1CE variant of Fab_L1 heavy chain, ... | | 著者 | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | | 登録日 | 2023-08-17 | | 公開日 | 2024-09-11 | | 最終更新日 | 2025-06-18 | | 実験手法 | X-RAY DIFFRACTION (4.6 Å) | | 主引用文献 | Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation.
Protein Sci., 34, 2025
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3CKH
 | | Crystal structure of Eph A4 receptor | | 分子名称: | Ephrin type-A receptor 4 | | 著者 | Shi, J.H, Song, J.X. | | 登録日 | 2008-03-15 | | 公開日 | 2008-09-23 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor.
J.Biol.Chem., 283, 2008
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6NKP
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6NJZ
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6NK1
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