6RW2

Bicycle Toxin Conjugate bound to EphA2

Summary for 6RW2

Entry DOI	10.2210/pdb6rw2/pdb
Descriptor	Ephrin type-A receptor 2, ALA-ARG-ASP-CYS-PRO-LEU-VAL-ASN-PRO-LEU-CYS-LEU-HIS-PRO-GLY-TRP-THR-CYS, GLYCEROL, ... (5 entities in total)
Functional Keywords	epha2, inhibitor, complex, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	24351.47
Authors	Brown, D.G.,Schroeder, S.,Chen, L. (deposition date: 2019-06-03, release date: 2020-04-08, Last modification date: 2020-05-06)
Primary citation	Mudd, G.E.,Brown, A.,Chen, L.,van Rietschoten, K.,Watcham, S.,Teufel, D.P.,Pavan, S.,Lani, R.,Huxley, P.,Bennett, G.S. Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads. J.Med.Chem., 63:4107-4116, 2020 Cited by PubMed: 32202781 DOI: 10.1021/acs.jmedchem.9b02129 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation