6RW2

Bicycle Toxin Conjugate bound to EphA2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ephrin type-A receptor 2	polymer	193	22006.7	1	UniProt (P29317) Pfam (PF01404)	Homo sapiens (Human)	Epithelial cell kinase,Tyrosine-protein kinase receptor ECK
2	B (B)	ALA-ARG-ASP-CYS-PRO-LEU-VAL-ASN-PRO-LEU-CYS-LEU-HIS-PRO-GLY-TRP-THR-CYS	polymer	18	1997.4	1		synthetic construct
3	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	D (B)	1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one	non-polymer		255.3	1	Chemie (29N)
5	E, F (A, B)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

A: 27 - 201 (UniProt: P29317)

PDB	External Database	Details
Ala 9	-	expression tag
Ser 10	-	expression tag
Arg 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
Gly 20	-	expression tag
Ala 21	-	expression tag
Ser 22	-	expression tag
Asp 23	-	expression tag
Asp 24	-	expression tag
Asp 25	-	expression tag
Asp 26	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	24004.1
Non-Polymers*	Number of molecules	2
	Total formula weight	347.4
All*	Total formula weight	24351.5

*Water molecules are not included.