8TV1

Structure of the EphA2 LBDCRD bound to FabS1C_L1

Summary for 8TV1

• Entry DOI: 10.2210/pdb8tv1/pdb
• Related: 8TRV 8TV2 8TV5
• Descriptor: S1C variant of Fab_L1 heavy chain, S1C variant of Fab_L1 light chain, Ephrin type-A receptor 2, ... (6 entities in total)
• Functional Keywords: cell signalling, antibody, agonist, high affinity, clustering, activation, signaling protein-immune system complex, signaling protein, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 82200.65

Authors

Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (deposition date: 2023-08-17, release date: 2024-06-26)

• Primary citation: Adams, J.J.,Bruce, H.A.,Ploder, L.,Garcia, J.,Khutoreskaya, G.,Jarvik, N.,Costa, L.E.,Gorelik, M.,Pot, I.,Sicheri, F.,Blazer, L.L.,Singer, A.U.,Sidhu, S.S.; Synthetic Antibodies targeting EPHA2 Induce Diverse Signaling-Competent Clusters with Differential Activation; To be published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)