3TB8
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6K6N
| Crystal structure of SIVmac239 Nef protein | 分子名称: | Protein Nef | 著者 | Hirao, K, Andrews, S, Kuroki, K, Kusaka, H, Tadokoro, T, Kita, S, Ose, T, Rowland-Jones, S, Maenaka, K. | 登録日 | 2019-06-04 | 公開日 | 2020-03-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.0002 Å) | 主引用文献 | Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation. Iscience, 23, 2020
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2NEF
| HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES | 分子名称: | NEGATIVE FACTOR (F-PROTEIN) | 著者 | Grzesiek, S, Bax, A, Clore, G.M, Gronenborn, A.M, Hu, J.S, Kaufman, J, Palmer, I, Stahl, S.J, Tjandra, N, Wingfield, P.T. | 登録日 | 1997-02-12 | 公開日 | 1997-07-07 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Refined solution structure and backbone dynamics of HIV-1 Nef. Protein Sci., 6, 1997
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2XI1
| Crystal structure of the HIV-1 Nef sequenced from a patient's sample | 分子名称: | NEF | 著者 | Yadav, G.P, Singh, P, Gupta, S, Tripathi, A.K, Tripathi, R.K, Ramachandran, R. | 登録日 | 2010-06-25 | 公開日 | 2011-08-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef. Plos One, 6, 2011
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5NUI
| Crystal structure of SIVmac239 Nef in an ExxxLM endocytic sorting motif bound state | 分子名称: | Protein Nef, SER-GLN-ILE-LYS-ARG-LEU-LEU-SER | 著者 | Manrique, S, Horenkamp, F.A, Anand, K, Geyer, M. | 登録日 | 2017-04-30 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat Commun, 8, 2017
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1AVV
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6B72
| A novel HIV-1 Nef dimer interface induced by a single octyl-glucoside molecule | 分子名称: | Protein Nef, octyl beta-D-glucopyranoside | 著者 | Wu, M, Augelli-Szafran, C.E, Ptak, R.G, Smithgall, T.E. | 登録日 | 2017-10-03 | 公開日 | 2018-02-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A single beta-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. PLoS ONE, 13, 2018
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6OWT
| Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex | 分子名称: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit sigma, ... | 著者 | Buffalo, C.Z, Ren, X, Hurley, J.H. | 登録日 | 2019-05-10 | 公開日 | 2019-09-25 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission. Cell Host Microbe, 26, 2019
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6URI
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4NEE
| crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef | 分子名称: | AP-2 complex subunit alpha-2, AP-2 complex subunit sigma, Protein Nef | 著者 | Hurley, J.H, Bonifacino, J.S, Ren, X, Park, S.Y. | 登録日 | 2013-10-29 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8841 Å) | 主引用文献 | How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4. Elife, 3, 2014
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3IK5
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3IOZ
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4EN2
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4EMZ
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4U5W
| Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ... | 著者 | Alvarado, J.J, Yeh, J.I, Smithgall, T.E. | 登録日 | 2014-07-25 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment. J.Biol.Chem., 289, 2014
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4ORZ
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7D7S
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7UX3
| Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes | 分子名称: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | 著者 | Hooy, R.M, Hurley, J.H. | 登録日 | 2022-05-04 | 公開日 | 2023-05-10 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | 主引用文献 | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Sci Adv, 8, 2022
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1EFN
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5NUH
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1AVZ
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6DFF
| Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer | 分子名称: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | 著者 | Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H. | 登録日 | 2018-05-14 | 公開日 | 2018-08-08 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
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6D83
| Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit | 分子名称: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | 著者 | Buffalo, C.Z, Morris, K.L, Hurley, J.H. | 登録日 | 2018-04-25 | 公開日 | 2018-08-08 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
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4D8D
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6CRI
| Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer | 分子名称: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | 著者 | Morris, K.L, Buffalo, C.Z, Hurley, J.H. | 登録日 | 2018-03-18 | 公開日 | 2018-08-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
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