6DFF

Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer

Summary for 6DFF

• Entry DOI: 10.2210/pdb6dff/pdb
• EMDB information: 7455
• Descriptor: Bone marrow stromal antigen 2, Nef protein chimera, AP-1 complex subunit beta-1, ADP-ribosylation factor 1, ... (8 entities in total)
• Functional Keywords: ap, hiv, nef, trafficking, viral protein, protein transport, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 306926.83

Authors

Morris, K.L.,Buffalo, C.Z.,Ren, X.,Hurley, J.H. (deposition date: 2018-05-14, release date: 2018-08-08, Last modification date: 2024-03-13)

• Primary citation: Morris, K.L.,Buffalo, C.Z.,Sturzel, C.M.,Heusinger, E.,Kirchhoff, F.,Ren, X.,Hurley, J.H.; HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.; Cell, 174:659-671.e14, 2018; PubMed: 30053425; DOI: 10.1016/j.cell.2018.07.004

Experimental method

ELECTRON MICROSCOPY (3.9 Å)