4ORZ

HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain

Summary for 4ORZ

• Entry DOI: 10.2210/pdb4orz/pdb
• Related: 3RBB 3REA
• Descriptor: Tyrosine-protein kinase HCK, Protein Nef, single domain antibody sdAb19, ... (4 entities in total)
• Functional Keywords: sh3 domain, immunglobolin fold, antibodies, epitopes, hiv antibodies, hiv accessory proteins, pxxp motif, complementarity determining regions, transferase-apoptosis-immune system complex, transferase/apoptosis/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Lysosome. Isoform 2: Cell membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle: P08631; Host cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P03407
• Total number of polymer chains: 3
• Total formula weight: 37439.97

Authors

Geyer, M.,Lulf, S. (deposition date: 2014-02-12, release date: 2014-03-26, Last modification date: 2023-09-20)

Primary citation

Lulf, S.,Matz, J.,Rouyez, M.C.,Jarviluoma, A.,Saksela, K.,Benichou, S.,Geyer, M.
Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Retrovirology, 11:24-24, 2014

PubMed Abstract: The HIV-1 Nef protein is essential for AIDS pathogenesis by its interaction with host cell surface receptors and signaling factors. Despite its critical role as a virulence factor Nef is not targeted by current antiviral strategies.

PubMed: 24620746
DOI: 10.1186/1742-4690-11-24

Experimental method

X-RAY DIFFRACTION (2 Å)