6D83

Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit

Summary for 6D83

• Entry DOI: 10.2210/pdb6d83/pdb
• EMDB information: 7453
• Descriptor: Bone marrow stromal antigen 2,Protein Nef, AP-1 complex subunit beta-1, ADP-ribosylation factor 1, ... (8 entities in total)
• Functional Keywords: ap, hiv, nef, trafficking, protein transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 306758.51

Authors

Buffalo, C.Z.,Morris, K.L.,Hurley, J.H. (deposition date: 2018-04-25, release date: 2018-08-08, Last modification date: 2024-03-13)

• Primary citation: Morris, K.L.,Buffalo, C.Z.,Sturzel, C.M.,Heusinger, E.,Kirchhoff, F.,Ren, X.,Hurley, J.H.; HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.; Cell, 174:659-671.e14, 2018; PubMed: 30053425; DOI: 10.1016/j.cell.2018.07.004

Experimental method

ELECTRON MICROSCOPY (4.27 Å)