4NEE

crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef

Summary for 4NEE

Entry DOI	10.2210/pdb4nee/pdb
Descriptor	AP-2 complex subunit sigma, AP-2 complex subunit alpha-2, Protein Nef (3 entities in total)
Functional Keywords	clathrin adaptor ap-2, hiv-1 nef, cd4 downregulation, viral protein-protein transport complex, viral protein/protein transport
Biological source	Rattus norvegicus (brown rat,rat,rats) More
Cellular location	Cell membrane: Q66HM2
Total number of polymer chains	12
Total formula weight	316395.85
Authors	Hurley, J.H.,Bonifacino, J.S.,Ren, X.,Park, S.Y. (deposition date: 2013-10-29, release date: 2014-01-29, Last modification date: 2023-09-20)
Primary citation	Ren, X.,Park, S.Y.,Bonifacino, J.S.,Hurley, J.H. How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4. Elife, 3:e01754-e01754, 2014 Cited by PubMed: 24473078 DOI: 10.7554/eLife.01754 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8841 Å)

Structure validation