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4NEE

crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef

Functional Information from GO Data
ChainGOidnamespacecontents
A0006886biological_processintracellular protein transport
A0016192biological_processvesicle-mediated transport
A0030117cellular_componentmembrane coat
B0006886biological_processintracellular protein transport
B0016192biological_processvesicle-mediated transport
B0030117cellular_componentmembrane coat
C0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0005905cellular_componentclathrin-coated pit
D0006886biological_processintracellular protein transport
D0006897biological_processendocytosis
D0008021cellular_componentsynaptic vesicle
D0008150biological_processbiological_process
D0015031biological_processprotein transport
D0016192biological_processvesicle-mediated transport
D0030117cellular_componentmembrane coat
D0030122cellular_componentAP-2 adaptor complex
D0035615molecular_functionclathrin adaptor activity
D0043231cellular_componentintracellular membrane-bounded organelle
D0045202cellular_componentsynapse
D0048488biological_processsynaptic vesicle endocytosis
D0071944cellular_componentcell periphery
D0072583biological_processclathrin-dependent endocytosis
D0098794cellular_componentpostsynapse
D0098884biological_processpostsynaptic neurotransmitter receptor internalization
D0098894cellular_componentextrinsic component of presynaptic endocytic zone membrane
D0098978cellular_componentglutamatergic synapse
E0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0005905cellular_componentclathrin-coated pit
F0006886biological_processintracellular protein transport
F0006897biological_processendocytosis
F0008021cellular_componentsynaptic vesicle
F0008150biological_processbiological_process
F0015031biological_processprotein transport
F0016192biological_processvesicle-mediated transport
F0030117cellular_componentmembrane coat
F0030122cellular_componentAP-2 adaptor complex
F0035615molecular_functionclathrin adaptor activity
F0043231cellular_componentintracellular membrane-bounded organelle
F0045202cellular_componentsynapse
F0048488biological_processsynaptic vesicle endocytosis
F0071944cellular_componentcell periphery
F0072583biological_processclathrin-dependent endocytosis
F0098794cellular_componentpostsynapse
F0098884biological_processpostsynaptic neurotransmitter receptor internalization
F0098894cellular_componentextrinsic component of presynaptic endocytic zone membrane
F0098978cellular_componentglutamatergic synapse
G0006886biological_processintracellular protein transport
G0016192biological_processvesicle-mediated transport
G0030117cellular_componentmembrane coat
H0005525molecular_functionGTP binding
I0005737cellular_componentcytoplasm
I0005886cellular_componentplasma membrane
I0005905cellular_componentclathrin-coated pit
I0006886biological_processintracellular protein transport
I0006897biological_processendocytosis
I0008021cellular_componentsynaptic vesicle
I0008150biological_processbiological_process
I0015031biological_processprotein transport
I0016192biological_processvesicle-mediated transport
I0030117cellular_componentmembrane coat
I0030122cellular_componentAP-2 adaptor complex
I0035615molecular_functionclathrin adaptor activity
I0043231cellular_componentintracellular membrane-bounded organelle
I0045202cellular_componentsynapse
I0048488biological_processsynaptic vesicle endocytosis
I0071944cellular_componentcell periphery
I0072583biological_processclathrin-dependent endocytosis
I0098794cellular_componentpostsynapse
I0098884biological_processpostsynaptic neurotransmitter receptor internalization
I0098894cellular_componentextrinsic component of presynaptic endocytic zone membrane
I0098978cellular_componentglutamatergic synapse
J0006886biological_processintracellular protein transport
J0016192biological_processvesicle-mediated transport
J0030117cellular_componentmembrane coat
K0005525molecular_functionGTP binding
L0005737cellular_componentcytoplasm
L0005886cellular_componentplasma membrane
L0005905cellular_componentclathrin-coated pit
L0006886biological_processintracellular protein transport
L0006897biological_processendocytosis
L0008021cellular_componentsynaptic vesicle
L0008150biological_processbiological_process
L0015031biological_processprotein transport
L0016192biological_processvesicle-mediated transport
L0030117cellular_componentmembrane coat
L0030122cellular_componentAP-2 adaptor complex
L0035615molecular_functionclathrin adaptor activity
L0043231cellular_componentintracellular membrane-bounded organelle
L0045202cellular_componentsynapse
L0048488biological_processsynaptic vesicle endocytosis
L0071944cellular_componentcell periphery
L0072583biological_processclathrin-dependent endocytosis
L0098794cellular_componentpostsynapse
L0098884biological_processpostsynaptic neurotransmitter receptor internalization
L0098894cellular_componentextrinsic component of presynaptic endocytic zone membrane
L0098978cellular_componentglutamatergic synapse
Functional Information from PROSITE/UniProt
site_idPS00989
Number of Residues11
DetailsCLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF
ChainResidueDetails
DILE57-PHE67

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305|PubMed:12086608, ECO:0000305|PubMed:25061211, ECO:0007744|PDB:2VGL, ECO:0007744|PDB:4UQI
ChainResidueDetails
GARG11
JLYS43
JTYR53
JLYS57
AARG11
ALYS43
ATYR53
ALYS57
GLYS43
GTYR53
GLYS57
BARG11
BLYS43
BTYR53
BLYS57
JARG11

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PDB entries from 2024-07-24

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