5NUH

Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain

Summary for 5NUH

• Entry DOI: 10.2210/pdb5nuh/pdb
• Related: 5NUI
• Descriptor: Protein Nef, Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK (3 entities in total)
• Functional Keywords: siv, virus, nef, sh3, transferase
• Biological source: Simian immunodeficiency virus (SIV); More
• Cellular location: Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631
• Total number of polymer chains: 4
• Total formula weight: 54432.66

Authors

Horenkamp, F.A.,Anand, K.,Geyer, M. (deposition date: 2017-04-30, release date: 2017-08-16, Last modification date: 2024-01-17)

• Primary citation: Manrique, S.,Sauter, D.,Horenkamp, F.A.,Lulf, S.,Yu, H.,Hotter, D.,Anand, K.,Kirchhoff, F.,Geyer, M.; Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.; Nat Commun, 8:442-442, 2017; PubMed: 28874665; DOI: 10.1038/s41467-017-00481-z

Experimental method

X-RAY DIFFRACTION (2.78 Å)