6CRI

Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer

Summary for 6CRI

Entry DOI	10.2210/pdb6cri/pdb
Related	6CRI
EMDB information	7455 7456 7457 7458 7563
Descriptor	Bone marrow stromal antigen 2, Protein Nef chimera, AP-1 complex subunit beta-1, ADP-ribosylation factor 1, ... (8 entities in total)
Functional Keywords	ap, hiv, nef, trafficking, viral protein, protein transport
Biological source	Homo sapiens (Human) More
Total number of polymer chains	24
Total formula weight	885692.75
Authors	Morris, K.L.,Buffalo, C.Z.,Hurley, J.H. (deposition date: 2018-03-18, release date: 2018-08-01, Last modification date: 2024-03-13)
Primary citation	Morris, K.L.,Buffalo, C.Z.,Sturzel, C.M.,Heusinger, E.,Kirchhoff, F.,Ren, X.,Hurley, J.H. HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174:659-671.e14, 2018 Cited by PubMed: 30053425 DOI: 10.1016/j.cell.2018.07.004 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (6.8 Å)

Structure validation