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6CRI

Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1T, N, c, Y, d...Bone marrow stromal antigen 2, Protein Nef chimerapolymer26429964.36UniProt (Q10589)
UniProt (Q90VU7)
Pfam (PF00469)
UniProt (by SIFTS) (P03404)
In PDB
Homo sapiens (Human)BST-2, HM1.24 antigen, Tetherin
2B, I, JAP-1 complex subunit beta-1polymer57064458.73UniProt (Q10567)
Pfam (PF01602)
In PDB
Homo sapiens (Human)Adaptor protein complex AP-1 subunit beta-1, Adaptor-related protein complex 1 subunit beta-1, Beta-1-adaptin, Beta-adaptin 1, Clathrin assembly protein complex 1 beta large chain, Golgi adaptor HA1/AP1 adaptin beta subunit
3C, H, K, U, L...ADP-ribosylation factor 1polymer16518936.66UniProt (P84077)
Pfam (PF00025)
In PDB
Homo sapiens (Human)Arf1
4G, Q, RAP-1 complex subunit gamma-1polymer58566401.13UniProt (P22892)
Pfam (PF01602)
In PDB
Mus musculus (Mouse)Adaptor protein complex AP-1 subunit gamma-1, Adaptor-related protein complex 1 subunit gamma-1, Clathrin assembly protein complex 1 gamma-1 large chain, Gamma-adaptin, Gamma1-adaptin, Golgi adaptor HA1/AP1 adaptin subunit gamma-1
5M, W, XAP-1 complex subunit mu-1polymer42248475.53UniProt (P35585)
Pfam (PF01217)
Pfam (PF00928)
In PDB
Mus musculus (Mouse)AP-mu chain family member mu1A, Adaptor protein complex AP-1 subunit mu-1, Adaptor-related protein complex 1 subunit mu-1, Clathrin assembly protein complex 1 mu-1 medium chain 1, Clathrin coat assembly protein AP47, Clathrin coat-associated protein AP47, Golgi adaptor HA1/AP1 adaptin mu-1 subunit, Mu-adaptin 1, Mu1A-adaptin
6S, a, bAP-1 complex subunit sigma-3polymer14216998.83UniProt (Q96PC3)
Pfam (PF01217)
In PDB
Homo sapiens (Human)Adaptor protein complex AP-1 subunit sigma-1C, Adaptor-related protein complex 1 subunit sigma-1C, Clathrin assembly protein complex 1 sigma-1C small chain, Golgi adaptor HA1/AP1 adaptin sigma-1C subunit, Sigma 1C subunit of AP-1 clathrin, Sigma-adaptin 1C, Sigma1C-adaptin
7H, K, U, L, V...GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.26Chemie (GTP)
8H, K, U, L, V...MAGNESIUM IONnon-polymer24.36Chemie (MG)
Sequence modifications
T, N, c, Y, d, Z: 2 - 21 (UniProt: Q10589)
PDBExternal DatabaseDetails
Met -26-expression tag
Ser -25-expression tag
Tyr -24-expression tag
Tyr -23-expression tag
His -22-expression tag
His -21-expression tag
His -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
Asp -16-expression tag
Tyr -15-expression tag
Asp -14-expression tag
Ile -13-expression tag
Pro -12-expression tag
Thr -11-expression tag
Thr -10-expression tag
Glu -9-expression tag
Asn -8-expression tag
Leu -7-expression tag
Tyr -6-expression tag
Phe -5-expression tag
Gln -4-expression tag
Gly -3-expression tag
Ala -2-expression tag
Met -1-expression tag
Gly 0-expression tag
Ser 1-expression tag
Gly 22-linker
Ser 23-linker
Asp 24-linker
Glu 25-linker
Ala 26-linker
Ser 27-linker
Glu 28-linker
Gly 29-linker
Ser 30-linker
Gly 31-linker
T, N, c, Y, d, Z: 32 - 237 (UniProt: Q90VU7)
B, I, J: 14 - 583 (UniProt: Q10567)
PDBExternal DatabaseDetails
Arg 359Lys 359engineered mutation
Lys 476Glu 476engineered mutation
C, H, K, U, L, V: 17 - 181 (UniProt: P84077)
PDBExternal DatabaseDetails
Leu 71Gln 71engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains24
Total formula weight882407.8
Non-Polymers*Number of molecules12
Total formula weight3284.9
All*Total formula weight885692.8
*Water molecules are not included.

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PDB entries from 2024-10-09

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