6OWT

Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex

Summary for 6OWT

• Entry DOI: 10.2210/pdb6owt/pdb
• EMDB information: 20217
• Descriptor: AP-2 complex subunit alpha, AP-2 complex subunit beta, Adaptor protein complex AP-2, mu1, ... (5 entities in total)
• Functional Keywords: ap, hiv, nef, trafficking, protein transport, viral restriction factor
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 267957.52

Authors

Buffalo, C.Z.,Ren, X.,Hurley, J.H. (deposition date: 2019-05-10, release date: 2019-09-25, Last modification date: 2019-12-18)

• Primary citation: Buffalo, C.Z.,Sturzel, C.M.,Heusinger, E.,Kmiec, D.,Kirchhoff, F.,Hurley, J.H.,Ren, X.; Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.; Cell Host Microbe, 26:359-368.e8, 2019; PubMed: 31447307; DOI: 10.1016/j.chom.2019.08.002

Experimental method

ELECTRON MICROSCOPY (3.8 Å)