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6OWT

Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0006886biological_processintracellular protein transport
A0015031biological_processprotein transport
A0016192biological_processvesicle-mediated transport
A0030117cellular_componentmembrane coat
A0030122cellular_componentAP-2 adaptor complex
A0030131cellular_componentclathrin adaptor complex
A0035615molecular_functionclathrin adaptor activity
A0072583biological_processclathrin-dependent endocytosis
B0006886biological_processintracellular protein transport
B0015031biological_processprotein transport
B0016192biological_processvesicle-mediated transport
B0030117cellular_componentmembrane coat
B0030276molecular_functionclathrin binding
M0006886biological_processintracellular protein transport
M0016192biological_processvesicle-mediated transport
M0030131cellular_componentclathrin adaptor complex
N0005525molecular_functionGTP binding
S0005886cellular_componentplasma membrane
S0005905cellular_componentclathrin-coated pit
S0006886biological_processintracellular protein transport
S0006897biological_processendocytosis
S0008021cellular_componentsynaptic vesicle
S0008150biological_processbiological_process
S0015031biological_processprotein transport
S0016020cellular_componentmembrane
S0016192biological_processvesicle-mediated transport
S0030117cellular_componentmembrane coat
S0030122cellular_componentAP-2 adaptor complex
S0035615molecular_functionclathrin adaptor activity
S0045202cellular_componentsynapse
S0048488biological_processsynaptic vesicle endocytosis
S0072583biological_processclathrin-dependent endocytosis
S0098794cellular_componentpostsynapse
S0098884biological_processpostsynaptic neurotransmitter receptor internalization
S0098894cellular_componentextrinsic component of presynaptic endocytic zone membrane
S0098978cellular_componentglutamatergic synapse
T0005525molecular_functionGTP binding
Functional Information from PROSITE/UniProt
site_idPS00989
Number of Residues11
DetailsCLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF
ChainResidueDetails
SILE57-PHE67

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P63010","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q96CW1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P53680","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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