6OWT
Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AP-2 complex subunit alpha | polymer | 939 | 104286.4 | 1 | UniProt (Q66HM2) Pfam (PF01602) Pfam (PF02883) Pfam (PF02296) UniProt (by SIFTS) (P18484) | Rattus norvegicus (Rat) | |
| 2 | B (B) | AP-2 complex subunit beta | polymer | 591 | 66953.2 | 1 | UniProt (P62944) Pfam (PF01602) | Rattus norvegicus (Rat) | AP105B,Adaptor protein complex AP-2 subunit beta,Adaptor-related protein complex 2 subunit beta,Beta-2-adaptin,Beta-adaptin,Clathrin assembly protein complex 2 beta large chain,Plasma membrane adaptor HA2/AP2 adaptin beta subunit |
| 3 | C (M) | Adaptor protein complex AP-2, mu1 | polymer | 141 | 16161.6 | 1 | UniProt (Q5FWI9) Pfam (PF01217) UniProt (by SIFTS) (P84091) | Mus musculus (Mouse) | |
| 4 | D, E (T, N) | Tetherin,Protein Nef | polymer | 275 | 31772.4 | 2 | UniProt (C3VHQ5) UniProt (Q4JGV0) Pfam (PF00469) | Cercocebus atys (Sooty mangabey) | |
| 5 | F (S) | AP-2 complex subunit sigma | polymer | 142 | 17011.7 | 1 | UniProt (P62744) Pfam (PF01217) | Rattus norvegicus (Rat) | Adaptor protein complex AP-2 subunit sigma,Adaptor-related protein complex 2 subunit sigma,Clathrin assembly protein 2 sigma small chain,Clathrin coat assembly protein AP17,Clathrin coat-associated protein AP17,Plasma membrane adaptor AP-2 17 kDa protein,Sigma-adaptin 3b,Sigma2-adaptin |
Sequence modifications
T, N: -4 - 16 (UniProt: C3VHQ5)
T, N: 29 - 270 (UniProt: Q4JGV0)
S: 1 - 142 (UniProt: P62744)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | Cys 9 | conflict |
| Ser 17 | - | linker |
| Lys 18 | - | linker |
| Gly 19 | - | linker |
| Ser 20 | - | linker |
| Asp 21 | - | linker |
| Glu 22 | - | linker |
| Ala 23 | - | linker |
| Ser 24 | - | linker |
| Glu 25 | - | linker |
| Gly 26 | - | linker |
| Ser 27 | - | linker |
| Gly 28 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| - | Tyr 28 | deletion |
| - | Gly 29 | deletion |
| - | Arg 30 | deletion |
| - | Leu 31 | deletion |
| - | Trp 32 | deletion |
| - | Glu 33 | deletion |
| - | Gly 34 | deletion |
| - | Leu 35 | deletion |
| - | Glu 36 | deletion |
| Ala 74 | Cys 55 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 97 | Asn 97 | engineered mutation |
| Ser 99 | Cys 99 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 267957.5 | |
| All* | Total formula weight | 267957.5 |
