4EMZ

HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain)

Summary for 4EMZ

• Entry DOI: 10.2210/pdb4emz/pdb
• Related: 4EN2
• Descriptor: Protein Nef, MHC-I, AP-1 complex subunit mu-1, ... (4 entities in total)
• Functional Keywords: human immunodeficiency virus 1, hiv, nef, mhc-i, antigen presentation, host defense, adaptor protein complex 1, mu1 adaptin subunit, sorting motif recognition, clasp, membrane trafficking, viral hijacking, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Golgi apparatus: P35585
• Total number of polymer chains: 6
• Total formula weight: 114364.78

Authors

Jia, X.,Xiong, Y. (deposition date: 2012-04-12, release date: 2012-06-20, Last modification date: 2012-07-25)

• Primary citation: Jia, X.,Singh, R.,Homann, S.,Yang, H.,Guatelli, J.,Xiong, Y.; Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.; Nat.Struct.Mol.Biol., 19:701-706, 2012; PubMed: 22705789; DOI: 10.1038/nsmb.2328

Experimental method

X-RAY DIFFRACTION (2.9 Å)